![Whatsapp mac](https://cdn1.cdnme.se/5447227/9-3/20_64e61dfc9606ee7f8b257166.png)
midazolam associated apnea is dose related and is also dependent on the rate of adminstration.may cause central respiratory depression.Therefore, some infants may not have adequate serum levels to provide adequate sedation. a large variation in the plasma concentration (up to 20x difference) has been reported in infants less than 1 year old.the sedative effect following IV administration is evident in 3 to 20 minutes the effectiveness has ranged in length from 2 to 12 hours.the metabolites are eliminated by the kidney therefore, patients in hepatic or kidney failure will likely require dosage modification.hepatic metabolism is predominately by the CYP3A enzyme erythromycin, for example can significantly inhibit the metabolism of midazolam, resulting in increased serum midazolam concentrations.midazolam is almost completely metabolized by the liver.midazolam, like other benzodiazepine, interacts with gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter, to produce a tranquilizing effect (limbic system), muscle relaxant effect (spinal cord) and hypnotic, sedative, and anticonvulsant effects (cerebral cortex).
![midazolam antidote midazolam antidote](https://image.slidesharecdn.com/midazolaminer1-120501012749-phpapp01/95/midazolam-in-er-1-8-728.jpg)
midazolam is a water-soluble benzodiazepine.it has also been used, after phenobarbital and phenytoin have failed, as an anticonvulsant.
![midazolam antidote midazolam antidote](https://rd-factsheets.de/wp-content/uploads/2020/10/midazolam.png)
![midazolam antidote midazolam antidote](https://cdn.shopify.com/s/files/1/0105/6761/4519/products/PN01255-main_94a5e576-024f-4a89-866c-5574e643e217_1024x.jpg)
![midazolam antidote midazolam antidote](https://medicalbrandnames.com/wp-content/uploads/2018/11/LOMDZ5.jpg)
If users of this Manual are not familiar with a drug, it is recommended that the official monograph be consulted before it is prescribed and administered. The information contained within the Manual may not be applicable to other centres. This Manual has been designed for use in the NICU at London Health Sciences Centre (LHSC), London, Ontario, Canada, and represents clinical practice at this institution.
![Whatsapp mac](https://cdn1.cdnme.se/5447227/9-3/20_64e61dfc9606ee7f8b257166.png)